LUTEIN AND ZEAXANTHIN
Lutein (L) and zeaxanthin (Z) are dietary carotenoids derived from dark green leafy vegetables, orange and yellow fruits that form the macular pigment of the human eyes.
LUTEIN AND ZEAXANTHIN
It was hypothesized that they protect against visual disorders and cognition diseases, such as
- age-related macular degeneration (AMD)
- age-related cataract (ARC)
- cognition diseases, ischemic/hypoxia induced retinopathy
- light damage of the retina
- retinitis pigmentosa
- retinal detachment
- uveitis
- diabetic retinopathy
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The meta-analysis revealed that lutein, zeaxanthin and meso-zeaxanthin supplementation improved MPOD both in AMD patients and healthy subjects with a dose-response relationship. This study evaluated 20 clinical trials involving 938 patients with macular degeneration and 826 control subjects. It showed that supplementation with the xanthophyll carotenoids, including lutein, zeaxanthin, and meso-zeaxanthin, was consistently associated with significant increases in macular pigment optical density, suggesting that this nutrient is an important addition to lutein/zeaxanthin supplements for eye health. Ma L et.al., Nutrients. 2016 Jul 12;8(7):426.
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In addition to their protective roles against light-induced oxidative damage, there are increasing evidences that L and Z may also improve normal ocular function by enhancing contrast sensitivity and by reducing glare disability. Surveys about L and Z supplementation have indicated that moderate intakes of L and Z are associated with decreased AMD risk and less visual impairment.
Reference
Jia YP, Sun L, Yu HS, Liang LP, Li W, Ding H, Song XB, Zhang LJ. The Pharmacological Effects of Lutein and Zeaxanthin on Visual Disorders and Cognition Diseases. Molecules. 2017 Apr 20;22(4):610. doi: 10.3390/molecules22040610. PMID: 28425969; PMCID: PMC6154331.
https://pubmed.ncbi.nlm.nih.gov/28425969/
Ma L, Liu R, Du JH, Liu T, Wu SS, Liu XH. Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density. Nutrients. 2016 Jul 12;8(7):426. doi: 10.3390/nu8070426. PMID: 27420092; PMCID: PMC4963902.
https://pubmed.ncbi.nlm.nih.gov/27420092/ https://www.lifeextension.com/magazine/2017/2/protect-eyes-from-computer-blue-light
https://healtect.com/lutein-zeaxanthin-vision/